130773-02-3

中文名称盐酸奈替康唑

英文名称 Neticonazole Hydrochloride

CAS 130773-02-3

分子式 C17H23ClN2OS

分子量 338.9

MOL 文件 130773-02-3.mol

更新日期 2024/07/08 16:38:18

130773-02-3 结构式

基本信息物理化学性质制备方法盐酸奈替康唑价格(试剂级) 常见问题列表

基本信息

中文别名

盐酸萘康唑
盐酸奈康唑
盐酸奈替康唑
(E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐

英文别名

SS-717
Atolant
Neticonazole hydrochloride
1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride
1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride
(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole hydrochloride
long-acting,colorectal,Neticonazole,antifungal,Neticonazole Hydrochloride,Imidazole,anti-cancer,nSMase2,Fungal,secretion,Inhibitor,p-ERK,anti-infection,inhibit,exosome

所属类别

有机原料：羧酸类化合物及衍生物

物理化学性质

熔点145-147°

储存条件-20°C储存

溶解度DMSO: 250 mg/mL (737.68 mM)

形态Solid

颜色White to off-white

制备方法

方法1

628-17-1

138206-46-9

130773-02-3

以1-碘戊烷和(E)-1-[2-甲巯基-1-[2-羟基苯基]乙烯基]-1H-咪唑为原料，合成(E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐的一般步骤如下：将式（4）化合物(E)-1-[1-(2-羟基苯基)-2-(甲硫基)乙烯基]-1H-咪唑（15.1 g，65 mmol）、氢氧化钾（5.1 g，91 mmol）和1-碘戊烷（15.55 g，78 mmol）溶于75 mL DMF中，室温搅拌反应3.5小时。反应完成后，将反应液倒入375 mL水中，用乙酸乙酯萃取，有机相依次用水和饱和食盐水洗涤。减压浓缩有机相，得到油状物。将该油状物溶于氯化氢气体饱和的乙酸乙酯中，搅拌10小时。反应液中析出白色固体，经过滤，用乙腈洗涤，真空干燥，得到16.4 g白色固体产物。产率：73.2%。HPLC纯度（面积归一化法）：99.61%，单一杂质含量<0.1%。

参考文献：

[1] Patent: CN107556245, 2018, A. Location in patent: Paragraph 0045; 0046

盐酸奈替康唑价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-128365	盐酸奈替康唑 Neticonazole hydrochloride	130773-02-3	25mg	650元
2025/05/22	HY-128365	盐酸奈替康唑 Neticonazole hydrochloride	130773-02-3	10 mM * 1 mLin DMSO	715元
2025/05/22	HY-128365	盐酸奈替康唑 Neticonazole hydrochloride	130773-02-3	50mg	950元

常见问题列表

生物活性

Neticonazole是咪唑类抗真菌剂，用于治疗皮肤真菌感染。

靶点

Fungal

体外研究

Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.

Western Blot Analysis

Cell Line:	C4-2B cells
Concentration:	10 µM
Incubation Time:	48 hours
Result:	Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.

体内研究

Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.

Animal Model:	Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage:	1 ng/kg, 10 ng/kg and 100 ng/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Significantly improved the survival of IDB mice with CRC xenograft tumors.