131614-02-3

中文名称 E 6123

英文名称 E 6123

CAS 131614-02-3

分子式 C23H22ClN5OS

分子量 451.972

MOL 文件 131614-02-3.mol

131614-02-3 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

化合物 T15188

英文别名

E 6123
E ?6123,E?6123
JEQVYSUCZLYBRQ-LBPRGKRZSA-N
4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-diMethyl-, (4S)- (9CI)

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

安全数据

危险性符号(GHS) GHS hazard pictograms

危险性描述N/A

防范说明N/A

常见问题列表

生物活性

E-6123 是一种血小板活化因子 (PAF) 受体拮抗剂。

靶点

PAF

体外研究

E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h.