131999-28-5

中文名称 131999-28-5

英文名称 1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-

CAS 131999-28-5

分子式 C22H20FN3O3

分子量 393.41

MOL 文件 131999-28-5.mol

131999-28-5 结构式

基本信息物理化学性质图谱信息常见问题列表

基本信息

中文别名

5-HT6/7拮抗剂1
化合物 5-HT6/7 ANTAGONIST 1

英文别名

5-HT6/7 antagonist 1
1H-Isoindole-1,3(2H)-dione, 2-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-

物理化学性质

沸点565.6±50.0 °C(Predicted)

密度1.346±0.06 g/cm3(Predicted)

酸度系数(pKa)7.86±0.10(Predicted)

图谱信息

131999-28-5(131999-28-5)核磁图(¹HNMR)

常见问题列表

生物活性

5-HT6/7 antagonist 1是多功能的 5-HT6/7/2A 和 D2 受体拮抗剂，但不与M1受体和hERG通道相互作用。

靶点

5-HT ₆ Receptor

5-HT ₇ Receptor

5-HT _2A Receptor

D ₂ Receptor

体外研究

Targeting 5-HT6 and/ or 5-HT7 receptors with antagonist drugs could constitute a promising strategy for treating symptoms of BPSD while avoiding some of the side effects of current antipsychotic drugs. Nevertheless, due to the complex pathology of dementia and accompanying behavioral and psychological symptoms, it seems unlikely that focusing on a single therapeutic target would be sufficient to provide adequate clinical benefit, and it is likely that successful development of novel anti-BPSD agents should involve a “designed” multifactorial approach.