133161-96-3
133161-96-3 结构式
基本信息
英文别名
PGDMTETRANOR-PGDM
TETRANOR-PROSTAGLANDIN D METABOLITE
(Z)-9α-11β-dihydroxy-15-oxo-2,3,18.19-tetranorprost-5-ene-1,20-dioic acid
Cyclopentanehexanoic acid, 2-[(2Z)-4-carboxy-2-buten-1-yl]-3,5-dihydroxy-γ-oxo-, (1R,2R,3S,5S)-
所属类别
石油化工：油脂类物理化学性质
沸点607.540±50.00 °C(Press: 760.00 Torr)(predicted)
密度1.296±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
储存条件-20°C储存
溶解度DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
酸度系数(pKa)4.347±0.10(predicted)
应用领域
用途一
Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. PGDM is a major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization. It is used as a biomarker to assess endogenous production of PGD2.