1331959-78-4

英文名称 HAC-Y6

CAS 1331959-78-4

分子式 C23H22N2O4

分子量 390.43

MOL 文件 1331959-78-4.mol

1331959-78-4 结构式

基本信息物理化学性质应用领域常见问题列表

基本信息

英文别名

HAC-Y6

物理化学性质

沸点533.7±50.0 °C(Predicted)

密度1.23±0.1 g/cm3(Predicted)

酸度系数(pKa)3.98±0.30(Predicted)

应用领域

用途一

HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules similarly to the effects of colchicine. HAC-Y6 exhibited its antitumor activity by disrupting microtubule assembly, causing cell cycle arrest and apoptosis through both extrinsic and intrinsic pathways in Hep3B cells. ( Oncol Rep. 2010 Nov;24(5):1169-78. )

常见问题列表

概述

HAC-Y6 通过细胞周期停滞发挥抗癌作用。HAC-Y6 诱导 COLO 205 细胞凋亡，IC50 为 0.52 µM。