1338483-67-2
1338483-67-2 结构式
基本信息
英文别名
AM-8508(S)-4-AMINO-6-((1-(6-FLUORO-1-(PYRIDIN-3-YL)-1H-BENZO[D]IMIDAZOL-2-YL)ETHYL)AMINO)PYRIMIDINE-5-CARBONITRILE
应用领域
用途一
AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.