133943-59-6
中文名称
H-LEU-ARG-PRO-OH
英文名称
H-LEU-ARG-PRO-OH
CAS
133943-59-6
分子式
C17H32N6O4
分子量
384.47
MOL 文件
133943-59-6.mol
更新日期
2025/10/17 15:00:03
133943-59-6 结构式
基本信息
中文别名
L-亮氨酰-L-精氨酰-L-脯氨酸 英文别名
LRPLeu-Arg-Pro
H-LEU-ARG-PRO-OH
LHRH 7-9 SEQUENCE
Leucylarginylproline
H-LEU-ARG-PRO-OH 2HCL
LHRH (7-9) SEQUENCE 2HCL
L-Proline,L-leucyl-L-arginyl-
物理化学性质
密度1.39±0.1 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble in DMSO
酸度系数(pKa)3.39±0.20(Predicted)
序列Leu-Arg-Pro
常见问题列表
生物活性
Leucylarginylproline是血管紧张素转换酶 (ACE) 抑制剂，IC50值为0.27μM。靶点
IC50: 0.27μM (ACE)
体外研究
Intravenous injection of Leucylarginylproline (30mg/kg) causes a decrease in the blood pressure. The maximum mean blood pressure reduction (about 15 mmHg) occurrs about 2 min after the injection. Leucylarginylproline peptide reduces the blood pressure by about 15 mmHg at the fourth hour and shows a maximal reduction effect of about 35 mmHg at the eighth hour after oral administration.