135304-07-3
135304-07-3 结构式
基本信息
中文别名
乙酰法尼基半胱氨酸N-乙酰基-L-法呢基半胱氨酸
N-乙酰基-S-法呢基-L-半胱氨酸
N-乙酰基-S-TRANS,TRANS-法尼基-L-半胱氨酸
英文别名
AFCAFC USP/EP/BP
AC-CYS(FARNESYL)-OH
Ac-L-Cys(Farnesyl)-OH
AC-CYSTEINE(FARNESYL)-OH
N-Acetyl-L-farnesylcysteine
n-acetyl-s-farnesylcysteine
ACETYL-S-FARNESYL-L-CYSTEINE
N-ACETYL-S-FARNESYL-L-CYSTEINE
N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
所属类别
生物化工：半胱氨酸类衍生物物理化学性质
沸点566.1±50.0 °C(Predicted)
密度1.038±0.06 g/cm3(Predicted)
储存条件-15°C
溶解度可溶于 DMSO（高达 25 mg/ml）或乙醇（高达 25 mg/ml）
酸度系数(pKa)3.31±0.10(Predicted)
形态淡黄色油状物。
颜色深黄色
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP5.860 (est)
常见问题列表
生物活性
Arazine (N-Acetyl-S-farnesyl-L-cysteine) 是 G 蛋白和 G 蛋白偶联受体 (G protein and G-protein coupled receptor) 信号传导的细胞渗透性调节剂。Arazine 可与异戊烯化的 G 蛋白或其受体位点竞争，成为异戊二烯基半胱氨酸甲基转移酶的底物。体外研究
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell.
体内研究
Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED 50 ) of 55±12 μg/20 μl.
| Animal Model: | TPA-induced ear acute inflammation in mouse |
| Dosage: | 2000 μg/20 μl |
| Administration: | 2000 μg/20 μl; Applied on ear |
| Result: | Inhibited ear edema, as measured by ear weight. |