1354198-41-6
中文名称
化合物 T27437
英文名称
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-
CAS
1354198-41-6
分子式
C17H12F3N5O3
分子量
391.3
MOL 文件
1354198-41-6.mol
1354198-41-6 结构式
基本信息
中文别名
化合物 T27437 英文别名
GS462808GS-462808
GS 462808
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-
应用领域
用途一
GS-462808 is a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. GS-462808 had lower brain penetration and serendipitously lower activity at the brain isoforms. GS-462808 has an improved CNS window , and improved anti-ischemic potency relative to ranolazine.