1354638-93-9
中文名称
(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇
英文名称
Araliadiol
CAS
1354638-93-9
分子式
C15H20O2
分子量
232.32
MOL 文件
1354638-93-9.mol
1354638-93-9 结构式
基本信息
中文别名
(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇 英文别名
Araliadiol(3S,8R,9Z)-1,9-Pentadecadiene-4,6-diyne-3,8-diol
1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3S,8R,9Z)-
常见问题列表
生物活性
Araliadiol 是从 Aralia cordata Thunb 的叶子中分离出来的一种聚炔化合物。Araliadiol 抑制 MCF-7 细胞生长，IC50 值为 6.41 µg/mL。靶点
IC50: 6.41 µg/mL (MCF-7 cells growth)
体外研究
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition.
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D
3
and cdk4 and an increase in the expression of p21 (WAF-1/Cip1).
Cell Cycle Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 20 µM, 40 µM, and 80 µM |
| Incubation Time: | 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours |
| Result: | The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). |
Western Blot Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 20 µM, 40 µM, and 80 µM |
| Incubation Time: | 48 hours |
| Result: | Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D 3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1). |