135661-44-8
135661-44-8 结构式
基本信息
磺基琥珀酰亚胺油酸钠
磺基琥珀酰亚胺基油酸酯
化合物SULFOSUCCINIMIDYL OLEATE
化合物SULFOSUCCINIMIDYL OLEATE SODIUM
Sulfosuccinimidyl Oleate Sodium
Sulfo-N-succinimidyl Oleate sodium
Sulphosuccinimyl oleate sodium salt
3-Pyrrolidinesulfonic acid, 2,5-dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-
inhibit,Sulfosuccinimidyl oleate,Mitochondrial Autophagy,Inhibitor,Mitophagy
(Z)-2,5-Dioxo-1-[(1-oxo-9-octadecenyl)oxy]-3-pyrrolidinesulfonic Acid Sodium
2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]-3-pyrrolidinesulfonic Acid Sodium
2,5-Dioxo-1-[[(9Z)-1-oxo-9-octadecenyl]oxy]pyrrolidine-3-sulphonic acid sodium salt
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-112847A | SULFOSUCCINIMIDYL OLEATE Sulfosuccinimidyl oleate sodium | 135661-44-8 | 5mg | 1900元 |
| 2024/04/30 | HY-112847A | SULFOSUCCINIMIDYL OLEATE Sulfosuccinimidyl oleate sodium | 135661-44-8 | 10mM * 1mLin DMSO | 2090元 |
| 2024/04/30 | HY-112847A | SULFOSUCCINIMIDYL OLEATE Sulfosuccinimidyl oleate sodium | 135661-44-8 | 10mg | 3200元 |
常见问题列表
Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability. Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability.
Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours).
Cell Viability Assay
| Cell Line: | BV2 cells |
| Concentration: | 20 μM and 50 μM |
| Incubation Time: | 24 hours |
| Result: | Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100 ng/mL LPS and 5 ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. |
Western Blot Analysis
| Cell Line: | BV2 cells |
| Concentration: | 50 μM |
| Incubation Time: | 24 hours |
| Result: | Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38. |
Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke.
| Animal Model: | 4-month-old male BALB/cABom mice with pMCAo model |
| Dosage: | 50 mg/kg |
| Administration: | Administered once by single oral gavage |
| Result: | Reduced brain damage following ischemia. Attenuated infarct size. |