1362911-19-0
1362911-19-0 结构式
物理化学性质
密度1.32±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度可溶于DMSO
酸度系数(pKa)7.05±0.46(Predicted)
形态Solid
颜色White to off-white
SMILESO=C(CC1=CC=CC=C1)OCOC(/N=C(NC(OCOC(CC2=CC=CC=C2)=O)=O)\NCCC[C@H](NS(C3=CC=C(C=C3)C)(=O)=O)C(OC)=O)=O
应用领域
用途一
ProTAME is an inhibitor of both APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, etoposide and doxorubicin, significantly increase cell death in Multiple Myeloma (MM) cell lines and primary cells, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.