136768-57-5
中文名称
N,N'-dimethyl-N,N'-bis(pyridin-2-ylmethyl)ethane-1,2-diamine
英文名称
N,N'-dimethyl-N,N'-bis(pyridin-2-ylmethyl)ethane-1,2-diamine
CAS
136768-57-5
分子式
C16H22N4
分子量
270.37
MOL 文件
136768-57-5.mol
更新日期
2026/11/04 16:10:18
136768-57-5 结构式
基本信息
中文别名
1,2-乙二胺,N,N'-二甲基-N,N'-双(2-吡啶基甲基)N,N'-二甲基-N,N'-双(2-吡啶基甲基)乙烷-1,2-二胺
N,N'-二甲基-N,N'-双(吡啶-2-基甲基)乙烷-1,2-二胺
N1,N2-二甲基-N1,N2-双(吡啶-2-基甲基)乙烷-1,2-二胺
英文别名
DK7707N,N'-Dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine
n,n'-dimethyl-n,n'-bis(2-pyridinylmethyl)-1,2-ethanediamine
N,N'-dimethyl-N,N'-bis(pyridin-2-ylmethyl)ethane-1,2-diamine
1,2-Ethanediamine, N,N'-dimethyl-N,N'-bis(2-pyridinylmethyl)-
N1,N2-dimethyl-N1,N2-bis(pyridin-2-ylmethyl)ethane-1,2-diamine
所属类别
材料化学：MOF配体物理化学性质
沸点359.1±32.0 °C(Predicted)
密度1.081±0.06 g/cm3(Predicted)
储存条件2-8°C, protect from light
酸度系数(pKa)6.75±0.50(Predicted)
外观Brown to dark brown Liquid
InChIInChI=1S/C16H22N4/c1-19(13-15-7-3-5-9-17-15)11-12-20(2)14-16-8-4-6-10-18-16/h3-10H,11-14H2,1-2H3
InChIKeyNJAHJMGPPKJUTO-UHFFFAOYSA-N
SMILESC(N(C)CC1=NC=CC=C1)CN(C)CC1=NC=CC=C1
应用领域
用途一
N,N''-Dimethyl-N,N''-bis(2-pyridylmethyl)ethane-1,2-diamine is an intermediate used in the synthesis of 8-Hydroxy Efavirenz (H941830), which is a metabolite of Efavirenz (E425000), a non-nucleoside HIV-1 reverse transcriptase inhibitor. Also, it is a potential candidates for bioreductively activated prodrug.参考文献
文献 1
[1] Magnetic exchange through hydrogen bonds: structural and magnetic characterization of cis-hydroxoaquachromium(III) complexes of tetradentate and monodentate ligands. https://doi.org/10.1021/ic00080a027
[2] Reductive Activation of O2 by Non-Heme Iron(II) Benzilate Complexes of N4 Ligands: Effect of Ligand Topology on the Reactivity of O2-Derived Oxidant. https://doi.org/10.1021/acs.inorgchem.6b02282
[3] Further Investigation of a Nickel‐Based Homogeneous Water Oxidation Catalyst with Two cis Labile Sites. https://doi.org/10.1002/cssc.201501474
[4] EPR, 1H and 2H NMR, and Reactivity Studies of the Iron–Oxygen Intermediates in Bioinspired Catalyst Systems. https://doi.org/10.1021/ic200088e