1402438-37-2

中文名称 N-[5-[7-[(2S)-1-hydroxypropan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]acetamide

英文名称 N-[5-[7-[(2S)-1-hydroxypropan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]acetamide

CAS 1402438-37-2

分子式 C24H20F3N5O3

分子量 483.443

MOL 文件 1402438-37-2.mol

1402438-37-2 结构式

基本信息应用领域

基本信息

中文别名

化合物 T28369

英文别名

PF6278121
PF06278121
PF 6278121
PF-6278121
PF-06278121
PF 06278121
N-[5-[7-[(2S)-1-hydroxypropan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl]-2-[4-(trifluoromethyl)phenyl]acetamide

应用领域

用途一

PF-06278121 is a potent and selective Trk inhibitor. PF-06278121 showed Trk A/B IC50 = 4/94 nM (enzymatic assay), Trk A/B/C IC50 = 13/7/6 nM (PathHunter cell assay), MDCK-MDR1 Papp (A-B) =< 1 X 10-6 cm/S.