1421837-45-7
物理化学性质
沸点693.8±55.0 °C(Predicted)
密度1.150±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 62.5 mg/mL (137.50 mM)
酸度系数(pKa)14.55±0.46(Predicted)
形态Solid
颜色White to off-white
TMP920价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 5mg | 800元 |
| 2025/05/22 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 10mM * 1mLin DMSO | 880元 |
| 2025/05/22 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 10mg | 1300元 |
常见问题列表
生物活性
TMP920 是一个高效、选择性的 RORγt 拮抗剂。TMP920 抑制 RORγt 结合 SRC1 肽的 IC50 值为 0.03 μM。靶点
IC50: 0.03 μM (RORγt)
体外研究
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4
+
T cells.
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro.
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro.
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets.
TMP920 significantly reduces RORγt-DNA interactions.
Cell Cytotoxicity Assay
| Cell Line: | Naïve CD4 + T cells |
| Concentration: | 0.09-30 μM |
| Incubation Time: | 48 hours |
| Result: | Has toxic effects on cell growth at >10 μM. |