145600-69-7
145600-69-7 结构式
基本信息
中文别名
化合物 T10253 英文别名
AD 0261Phenol, 2-[[3-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]propyl]amino]-4-methyl-
常见问题列表
生物活性
AD 0261是一种自由基清除剂，能够有效抑制脂质过氧化物和超氧化物阴离子的产生。体外研究
AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC 50 =0.022 μM) and superoxide anions (IC 50 = 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC 50 value being around 1.0 μM.