146064-00-8

中文名称化合物 T23958

英文名称 dactylocycline D

CAS 146064-00-8

分子式 C33H42ClN3O14

分子量 740.16

MOL 文件 146064-00-8.mol

146064-00-8 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

指孢环素 D
化合物 T23958

英文别名

dactylocycline D
2-Naphthacenecarboxamide, 6-[[3-[(acetyloxy)amino]-2,3,6-trideoxy-3-C-methyl-4-O-methyl-α-L-arabino-hexopyranosyl]oxy]-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,4a,10,12,12a-pentahydroxy-8-methoxy-6-methyl-1,11-dioxo-, [4R-(4α,4aα,5aα,6α,12aα)]- (9CI)

物理化学性质

沸点930.2±75.0 °C(Predicted)

密度1.56±0.1 g/cm3(Predicted)

酸度系数(pKa)4.50±1.00(Predicted)

应用领域

用途一

Dactylocyclines is novel tetracycline derivatives produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline.