1470302-79-4
1470302-79-4 结构式
基本信息
中文别名
化合物 T13417 英文别名
ZYZ-488β-D-Glucopyranosiduronic acid, 4-[[4-[(aminoiminomethyl)amino]butoxy]carbonyl]-2,6-dimethoxyphenyl
物理化学性质
沸点700.6±70.0 °C(Predicted)
密度1.57±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 200 mg/mL (410.29 mM)
酸度系数(pKa)2.75±0.70(Predicted)
形态Solid
颜色White to off-white
ZYZ-488价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-100472 | ZYZ-488 | 1470302-79-4 | 1 mg | 1590元 |
| 2025/05/22 | HY-100472 | ZYZ-488 ZYZ-488 | 1470302-79-4 | 5mg | 3500元 |
| 2025/05/22 | HY-100472 | ZYZ-488 ZYZ-488 | 1470302-79-4 | 10mM * 1mLin DMSO | 3850元 |
常见问题列表
生物活性
ZYZ-488 是一种竞争性凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂，抑制结合蛋白 procaspase-9 和 procaspase-3 的激活。靶点
Apoptotic protease activating factor-1
体外研究
ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3.
ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases.
体内研究
ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis.
| Animal Model: | Male C57BL/6 mice (8-10 weeks old) |
| Dosage: | myocardial infarction + ZYZ-488 (33.9 mg/kg); myocardial infraction + ZYZ-488 (67.8 mg/kg); |
| Administration: | Intramuscularly; for 3 days |
| Result: | Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3. |