1472624-85-3
1472624-85-3 结构式
基本信息
7-[苄基(甲基)氨基]-2-氧代-2H-苯并吡喃-3-羧酸
7ACC-2
7ACC 2
7ACC 2
7ACC-2
7ACC 2
7ACC-2
7-[benzyl(methyl)amino]-2-oxochromene-3-carboxylic acid
7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
2H-1-Benzopyran-3-carboxylic acid, 7-[methyl(phenylmethyl)amino]-2-oxo-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-D0713 | 7ACC-2 7ACC2 | 1472624-85-3 | 2mg | 600元 |
| 2025/02/08 | HY-D0713 | 7ACC-2 7ACC2 | 1472624-85-3 | 5mg | 900元 |
| 2025/02/08 | HY-D0713 | 7ACC-2 7ACC2 | 1472624-85-3 | 10mM * 1mLin DMSO | 1021元 |
常见问题列表
| Target | Value |
|
MCT1
() |
7ACC2 (compound 19; 72 hours) inhibits SiHa cells proliferation in lactate-containing medium with an EC50 of 0.22 μM. In SiHa cells, lactate uptake primarily depends on the high affinity MCT1 transporter.
7ACC2 (compound 19) shows an excellent chemical stability in simulated gastric (SGF) and intestinal (SIF) fluids, a good apparent permeability coefficient (Papp) through Caco-2 monolayer and a high metabolic stability on mouse (MLM) and human liver microsomes (HLM) as well as on human hepatocytes.
7ACC2 is a potent inhibitor of mitochondrial pyruvate transport which consecutively blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation.
7ACC2 (3 mg/kg; intraperitoneal administration; daily; for 5 days or 10days) treatment significantly inhibits tumor growth in mice. 7ACC2 radiosensitizes tumor cells by reducing hypoxia in vivo.
The intraperitoneal administration of 7ACC2 (compound 19; 3 mg/kg) to mice leads to a C
max
of 1246 ng/ml (4 μM) in a very short time (T
max
=10 min) associated with a plasma half-life of 4.5 h.
| Animal Model: | 7-week-old female NMRI nude mice with radiotherapy administered |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal administration; daily; for 5 days or 10days |
| Result: | A significant increase in tumor growth delay was observed. |