148498-78-6
中文名称
TYR-ARG-GLN-SER-MET-ASN-ASN-PHE-GLN-GLY-LEU-ARG-SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2(DISULFIDE BRIDGE:CYS16-CYS21)
英文名称
ADRENOMEDULLIN (HUMAN)
CAS
148498-78-6
分子式
C264H406N80O77S3
分子量
6028.73
MOL 文件
148498-78-6.mol
更新日期
2026/01/22 21:11:19
148498-78-6 结构式
基本信息
中文别名
YY-52-NH2肾上腺髓质素(ADM)(1~12),人
ADRENOMEDULLIN (1-52) (人)
英文别名
ADM 1-52, HUMANhumanadrenomedullin
ADRENOMEDULLIN (HUMAN)
adrenomedullin 52 human
ADRENOMEDULLIN 1-52, HUMAN
Human adrenomedullin-(1-52)-NH2
Adrenomedullin (human)/ADM (1-52) (human), Adrenomedullin (1-52), human
YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2 (DISULFIDE BRIDGE: 16-21)
Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-
TYR-ARG-GLN-SER-MET-ASN-ASN-PHE-GLN-GLY-LEU-ARG-SER-PHE-GLY-CYS-ARG-PHE-GLY-THR-CYS-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2
物理化学性质
储存条件-20°C
溶解度在1%乙酸中溶解度为1mg/ml
形态powder
序列H-Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2(Disulfide bond)
应用领域
多肽
肾上腺髓质素（daernomdeulni,ADM）首先是在人手术切除的嗜铬细胞瘤组织中分离出来的一种具有扩血管和利尿活性的多肽。Adrenomedullin (human)以相当的浓度存在于人的血浆中，参与血压的调控。Adrenomedullin (human)由52个氨基酸组成，在固相多肽合成中属于序列相对较长的多肽，并且结构中还有一对二硫键。参考质量标准
外观:白色粉末纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
常见问题列表
生物活性
Adrenomedullin (AM) (1-52), human 是一种含有 52 个氨基酸的多肽，影响癌细胞增殖和血管生成。体外研究
To explore the effect of Adrenomedullin (AM) (1-52), human on astroglioma cells, CRT-MG cells are incubated in the absence or presence of Adrenomedullin (AM) (1-52), human (ADM1-52) for 48 h in a medium containing 1% FBS, and wound-healing assay is performed. The number of cells migrating to the wound region significantly increases in the ADM1-52-treated cells, in a dose-dependent manner, compared to the untreated cells.