1493762-74-5
1493762-74-5 结构式
基本信息
中文别名
化合物 T10563 英文别名
BM635Morpholine, 4-[[1-(4-fluorophenyl)-2-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrrol-3-yl]methyl]-
物理化学性质
沸点500.3±50.0 °C(Predicted)
密度1.12±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 31 mg/mL (78.98 mM)
酸度系数(pKa)6.70±0.10(Predicted)
形态Solid
颜色White to off-white
BM635价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-109587 | BM635 BM635 | 1493762-74-5 | 5mg | 650元 |
| 2025/05/22 | HY-109587 | BM635 BM635 | 1493762-74-5 | 10mg | 1050元 |
| 2025/05/22 | HY-109587 | BM635 BM635 | 1493762-74-5 | 25mg | 2100元 |
常见问题列表
生物活性
BM635是 MmpL3 的抑制剂， 具有出色的抗分歧杆菌活性。抑制结合分歧杆菌H37Rv的MIC50 值为0.12 μM。靶点
MIC50: 0.12 μM (M. tuberculosis H37Rv)
体内研究
BM635 has potent MIC (0.12 µM), Tox 50 :MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED 99 of 49 mg/Kg (IC 95% : 43–54 mg/Kg). The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (C max =1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo .