150493-34-8

中文名称 150493-34-8

英文名称 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

CAS 150493-34-8

分子式 C15H11ClF3N3

分子量 325.72

MOL 文件 150493-34-8.mol

150493-34-8 结构式

基本信息物理化学性质安全数据 150493-34-8价格(试剂级) 常见问题列表

基本信息

中文别名

化合物NS 638
1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺
1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺, >98%

英文别名

NS 638
NS638, >98%
NS-638
NS 638
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点476.3±55.0 °C(Predicted)

密度1.45±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol

酸度系数(pKa)5.15±0.10(Predicted)

形态固体

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

150493-34-8价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-101428	150493-34-8 NS-638	150493-34-8	2mg	500元
2024/04/30	HY-101428	150493-34-8 NS-638	150493-34-8	10mM * 1mLin DMSO	896元
2024/04/30	HY-101428	150493-34-8 NS-638	150493-34-8	5mg	940元

常见问题列表

生物活性

NS-638是具有阻断Ca2+-离子通道性质的非肽类小分子。细胞内阻断由K+激活的Ca2+浓度升高的IC50值为3.4 μM。

靶点

IC50: 3.4 μM (K ⁺ -stimulated intracellular Ca ²⁺ -elevation)

体外研究

NS-638 dose dependently inhibits K ⁺ -stimulated [45 Ca ²⁺ ]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [ ³ H]GABA-release from cultured cortical neurons with IC ₅₀ values of 2.3 and 4.3 μM, respectively. K ⁺ -stimulated intracellular Ca ²⁺ -elevation in cultured cerebellar granule cells is equipotently blocked with an IC ₅₀ value of 3.4 μM. At this concentration no effect on Ca ²⁺ -induced contractions in K ⁺ -depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca ²⁺ -channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM.

体内研究

In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.