150651-39-1

中文名称 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile

英文名称 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile

CAS 150651-39-1

分子式 C20H13N5

分子量 323.35

MOL 文件 150651-39-1.mol

更新日期 2025/09/01 12:37:49

150651-39-1 结构式

基本信息物理化学性质安全数据图谱信息 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile价格(试剂级) 常见问题列表

基本信息

中文别名

化合物IFSP1
1-氨基-3-(对甲苯基)苯并[4,5]咪唑并[1,2-A]吡啶-2,4-二甲腈

英文别名

iFSP1
1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile, 1-amino-3-(4-methylphenyl)-

物理化学性质

密度1.31±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMSO:30.0(Max Conc. mg/mL);92.78(Max Conc. mM)

酸度系数(pKa)2.90±0.50(Predicted)

形态结晶固体

颜色Light yellow to yellow

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H332-H302-H335-H315-H319-H312

防范说明P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312

图谱信息

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile(150651-39-1)核磁图(¹HNMR)

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-136057	iFSP1	150651-39-1	5 mg	300元
2025/05/22	HY-136057	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile iFSP1	150651-39-1	10mg	480元
2025/05/22	HY-136057	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile iFSP1	150651-39-1	10mM * 1mLin DMSO	530元

常见问题列表

生物活性

iFSP1 是一种有效的、选择性的且不依赖谷胱甘肽的 ferroptosis suppressor protein 1 (FSP1/AIFM2) 的抑制剂，EC50值为103 nM。iFSP1 可在过表达FSP1的GPX4基因敲除的Pfa1细胞和HT1080细胞中选择性诱导铁死亡。

靶点

Target	Value
FSP1/AIFM2 (Cell-free assay)	103 nM(EC50)

体外研究

iFSP1 (0.001-1 μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.iFSP1 (0.001-1 μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.iFSP1 (3 μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1)

Cell Proliferation Assay

Cell Line:	Wild-type and Gpx4-knockout Pfa1 or HT 1080 cells overexpressing FSP1–HA
Concentration:	0.001-1 μM
Incubation Time:	24 hours
Result:	Was toxic to cells that depend solely (no GPX4 expression detectable) on FSP1 function.

Cell Viability Assay

Cell Line:	NCl-H1437, NCl-H1437 FSP1 KO, U-373, U-373 FSP1 KO, MDA-MB-436, MDA-MB-436 FSP1 KO, SW620, SW620 FSP1 KO, MDA-MB-435S, MDA-MB-435S FSP1 KO, A549 and A549 FSP1 KO
Concentration:	3 μM
Incubation Time:	24 hours
Result:	Sensitized a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3.