151804-79-4
中文名称
AMYLIN拮抗剂多肽AC 253
英文名称
AC253
CAS
151804-79-4
分子式
C122H196N40O39
分子量
2847.15
MOL 文件
151804-79-4.mol
151804-79-4 结构式
基本信息
中文别名
AMYLIN拮抗剂多肽AC 253 英文别名
AC253AC253 trifluoroacetate
L-Tyrosinamide, N-acetyl-L-leucylglycyl-L-arginyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-arginyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-seryl-L-asparaginyl-L-threonyl- (9CI)
物理化学性质
密度1.53±0.1 g/cm3(Predicted)
序列Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2
常见问题列表
生物活性
AC 253 is an Amylin (AMY3) receptor antagonist, inhibiting andrenomedulin-stimulated cAMP production. AC 253 protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. AC 253 blocks electrophysiological effects of Aβ.