151837-09-1
中文名称
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
英文名称
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
CAS
151837-09-1
分子式
C16H27N6O5PS
分子量
446.46
MOL 文件
151837-09-1.mol
151837-09-1 结构式
基本信息
中文别名
(R)-腺苷 环3',5'-(硫代磷酸氢酯)三乙胺盐 英文别名
RP-CAMPS TEACAMPS TEA, RP-ISOMER
OXIPZMKSNMRTIV-RNSTXJOVSA-N
RP-CAMPS TRIETHYL AMMONIUM SALT
CAMPS-RP, TRIETHYLAMMONIUM SALT
rp-camps triethylammonium salt hydrate
Rp-Cyclic AMPS (triethylammonium salt)
ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-RP, TRIETHYLAMMONIUM SALT
Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt
Rp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine triethylammonium salt
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-100530 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT Rp-cAMPS triethylammonium salt | 151837-09-1 | 1mg | 6750元 |
常见问题列表
生物活性
Rp-cAMPS triethylammonium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。靶点
Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)
体外研究
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
体内研究
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.