152831-00-0
中文名称
6-羟基苯溴马隆
英文名称
(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone
CAS
152831-00-0
分子式
C17H12Br2O4
分子量
440.08
MOL 文件
152831-00-0.mol
152831-00-0 结构式
基本信息
中文别名
6-羟基苯溴马隆6-羟基苯并溴马隆
苯溴马隆杂质7(6-羟基苯溴马隆)
BENZBROMARONE杂质7-13C3-D2(6-羟基-BENZBROMARONE-13C3-D2)
英文别名
Benzbromarone Impurity 10Benzbromarone 6-Hydroxy Impurity
Benzbromarone Impurity 7 (6-Hydroxy-Benzbromarone)
Benzbromarone Impurity 10 (6-Hydroxy-Benzbromarone）
(3,5-dibromo-4-hydroxyphenyl)(2-ethyl-6-hydroxybenzofuran-3-yl)methanone
METHANONE,(3,5-DIBROMO-4-HYDROXYPHENYL)(2-ETHYL-6-HYDROXY-3-BENZOFURANYL)-
物理化学性质
沸点444.9±45.0 °C(Predicted)
密度1.785±0.06 g/cm3(Predicted)
储存条件-20°C储存
酸度系数(pKa)4.53±0.25(Predicted)
形态Solid
颜色Off-white to light yellow
常见问题列表
生物活性
6-Hydroxybenzbromarone 是 Benzbromarone 的主要代谢产物 (metabolite)，比母体化合物具有更长的半衰期和更大的药理效力。6-Hydroxybenzbromarone 是一种 EYA3 抑制剂，IC50 值为 21.5 μM。6-Hydroxybenzbromarone 是一种血管生成剂，对细胞迁移，肾小管生成和血管生成具有强大的抑制作用。靶点
IC50: 21.5 μM (EYA3); metabolite
体外研究
6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding.
Cell Proliferation Assay
| Cell Line: | HUVEC cells |
| Concentration: | 7.5 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited HUVEC cells proliferation. |