1544739-76-5

中文名称化合物 MK-8666

英文名称 Cyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, 3-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-5,5a,6,6a-tetrahydro-, (5aS,6R,6aR)-

CAS 1544739-76-5

分子式 C29H31NO6S

分子量 521.62

MOL 文件 1544739-76-5.mol

1544739-76-5 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 MK-8666

英文别名

Cyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, 3-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-5,5a,6,6a-tetrahydro-, (5aS,6R,6aR)-

物理化学性质

沸点741.8±60.0 °C(Predicted)

密度1.304±0.06 g/cm3(Predicted)

酸度系数(pKa)3.94±0.20(Predicted)

应用领域

用途一

MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancreatic beta cells and in intestinal enteroendocrine cells. Thus, MK-8666 has been investigated for treatment of type 2 diabetes mellitus and has been shown to robustly lower glucose without negative effects.