159190-45-1

中文名称 L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

英文名称 L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE

CAS 159190-45-1

分子式 C8H19Cl2N3O2

分子量 260.16

MOL 文件 159190-45-1.mol

159190-45-1 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

中文别名

化合物 T25749

英文别名

L-NIL HCL
L-NIL DIHYDROCHLORIDE
L-N6-(1-Iminoethyl)lysine
OQIBCXRAFAHXMM-KLXURFKVSA-N
L-N6-(1-IMINOETHYL)-LYSINE 2HCL
L-N6-(1-IMINOETHYL)LYSINE, DIHCL
L-Lysine ω-acetamidine dihydrochloride
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2)

物理化学性质

储存条件-20°C

溶解度DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml

形态白色至类白色固体

生物来源synthetic (organic)

水溶解性water: 50mg/mL, clear, colorless

InChI1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1

InChIKeyOQIBCXRAFAHXMM-KLXURFKVSA-N

SMILESCl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H315-H319-H335

防范说明P261-P305+P351+P338

危险品标志Xi

危险类别码36/37/38

安全说明37/39-26-36

WGK Germany3

存储类别11 - Combustible Solids

危险性类别Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

常见问题列表

生物活性

L-NIL dihydrochloride 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂，其对 miNOS 的 IC50 值为3.3 μM。

靶点

IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase).

体外研究

L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC ₅₀ values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.

体内研究

L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.

Animal Model:	Adult male Balb/c (20-25 g).
Dosage:	10 and 30 mg/kg.
Administration:	Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
Result:	Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.