1596362-29-6
中文名称
(S)-N-((S)-1-((环己基甲基)氨基)-5-胍基-1-氧代戊烷-2-基)-2-(4-氧代-4-苯基丁酰基)-1,2,3,4-四氢异喹啉-3-甲酰胺盐酸盐
英文名称
PS372424 hydrochloride
CAS
1596362-29-6
分子式
C33H45ClN6O4
分子量
625.21
MOL 文件
1596362-29-6.mol
1596362-29-6 结构式
基本信息
中文别名
(S)-N-((S)-1-((环己基甲基)氨基)-5-胍基-1-氧代戊烷-2-基)-2-(4-氧代-4-苯基丁酰基)-1,2,3,4-四氢异喹啉-3-甲酰胺盐酸盐 英文别名
PS372424 hydrochloride常见问题列表
生物活性
PS372424 hydrochloride，CXCL10 的三个氨基酸片段，是一种特异的人 CXCR3 激动剂，具有抗炎活性。在关节炎炎症模型中，PS372424 hydrochloride 可抑制 T 细胞迁移。靶点
|
Human CXCR3
|
体外研究
PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation.
PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3
+
T cells not in CXCR3
-
T cells.
PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC
50
of 42±21 nM.
Western Blot Analysis
| Cell Line: | CXCR3 + T cells and CXCR3 - T cells |
| Concentration: | 10, 50, 100, or 200 nM |
| Incubation Time: | 30 minutes |
| Result: | Caused a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells. Did not result in phosphorylation of CCR5 on CXCR3 - T cells. |