166526-99-4
166526-99-4 结构式
基本信息
Agomelatine 3-Hydroxy Impurity
N-[2-(7-methoxy-3-hydroxynaphth-1-yl)ethyl]-acetamide
N-(2-(3-Hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide
Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]-
Agomelatine impurity 1/3-Hydroxy Agomelatine/N-[2-(3-Hydroxy-7-methoxy-1-naphthalenyl)ethyl]acetamide
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-133111 | 3-羟基阿戈美拉汀D3 3-Hydroxy agomelatine | 166526-99-4 | 5mg | 1700元 |
| 2025/02/08 | HY-133111 | 阿戈美拉汀杂质 3-Hydroxy agomelatine | 166526-99-4 | 10 mM * 1 mLin DMSO | 1870元 |
| 2025/02/08 | HY-133111 | 阿戈美拉汀杂质 3-Hydroxy agomelatine | 166526-99-4 | 10 mg | 2800元 |
常见问题列表
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5-HT 2C Receptor 3.2 μM (IC 50 ) |
5-HT 2C Receptor 1.8 μM (Ki) |
Agomelatine and S 21517 have moderately high affinities for 5-HT 2C receptors ( K i = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity ( K i = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10 -7 -10 -4 M) are antagonists at 5-HT 2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine.
Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat.