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1678416-08-4

中文名称 荧光标记淀粉样蛋白肽(1-40)
英文名称 5-FAM-Amyloid β-Protein (1-40)
CAS 1678416-08-4
更新日期 2025/06/09 08:58:18
1678416-08-4 结构式 1678416-08-4 结构式

基本信息

中文别名
荧光标记淀粉样蛋白肽(1-40)
英文别名
Fam-βAmyloid(1-40)
β-Amyloid (1-40), FAM-labeled
5-FAM-Amyloid β-Protein (1-40)
5-FAM-Amyloid b-Protein (1-40) trifluoroacetate salt
5-FAM-Amyloid β-Protein (1-40) trifluoroacetate salt

物理化学性质

序列FAM-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

常见问题列表

生物活性
β-Amyloid (1-40), FAM-labeled 是一个 FAM 荧光标记的 β-Amyloid (1-40) 肽 (λex= 492 nm and λem= 518 nm)。
靶点

λ ex = 492 nm; λ em = 518 nm

体外研究

Apical-to-basolateral exchange across endothelial monolayer of fluorescent Aβ42 (FAM-labeled Human β-Amyloid (1-42) and Fluor 488-labeled β-Amyloid (1-42)) or scramble Aβ42 ( FAM-labeled scrambled β-Amyloid (1-42) ) (1-100 μM) is monitored in transendothelial electrical resistance (TEER) during cell monolayer’s formation over time (over 120 min in presence or absence of Aβ24). Human β-Amyloid (1-24) (1 μM) results in H-Aβ42 retention, thus reducing its efflux through the BBB and therefore preventing an efficient mechanism of Aβ42 clearance.The in vitro BBB model is used to investigate the passage of FAM-labeled or 488-conjugated H-Aβ42 across the endothelial cell monolayer. The addition of fluorescently labeled H-Aβ42 (FAM-labeled Human β-Amyloid (1-42) or Fluor 488-labeled β-Amyloid (1-42)) to the apical side of cell inserts results in effective BBB crossing, FAM-labeled scrambled β-Amyloid (1-42) is not efficiently transcytosed.

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