16846-24-5
基本信息
交沙霉素
交沙毒素
交沙箏素
交沙霉素 标准溶液
交沙霉素 EP标准品
交沙霉素峰鉴别 EP标准品
交沙霉素溶液,100PPM
交沙霉素溶液, 1000PPM
LEUCOMYCIN A3[干冰运输]
EN 141
Jomybel
YL-704A3
Iosalide
Josacine
Josamina
Wilprafen
Vilprafen
JOSAMYCIN
物理化学性质
常见问题列表
Kd: 5.5 nM (ribosome)
Studies show that the average lifetime on the ribosome is 3 h for Josamycin and that the dissociation constants for Josamycin binding to the ribosome is 5.5 nM. Josamycin slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and completely inhibits formation of the second or third peptide bond, depending on peptide sequence at a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin. At a saturating drug concentration, synthesis of fulllength proteins is completely shut down by Josamycin.
Blood and tissue levels of Josamycin after oral administration are 200 mg/kg to rabbits. Tissue levels are generally much higher than the blood levels, and 3 h after the administration, when the blood level is very low, the tissue levels are rather higher than those 1 h after the dose. One hour after the medication, the level in the lungs is the highest of all the tissue levels.