1685280-21-0
1685280-21-0 结构式
基本信息
中文别名
化合物DMH-25化合物DMH-25,10 MM DMSO 溶液
英文别名
DMH-256,8-dibromo-2-(4-bromophenyl)-3-nitro-2H-chromene
应用领域
用途一
DMH25 is a novel covalent and potent mTOR inhibitor, which shows in vivo antitumor activity against triple-negative breast cancer cells. ation. DHM25 was shown to be a selective and covalent inhibitor of mTOR using biochemical and cellular analyses, modeling, and a large panel of kinase activity assays spanning the human kinome (243 kinases). In vivo, DHM25 was an efficient inhibitor of growth and metastasis of triple-negative breast cancer cells, paving the way for its clinical application in oncology. Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers.