170846-74-9
中文名称
CHPG
英文名称
CHPG
CAS
170846-74-9
分子式
C8H8ClNO3
分子量
201.61
MOL 文件
170846-74-9.mol
更新日期
2025/05/20 14:02:44
170846-74-9 结构式
基本信息
中文别名
化合物 T10809 英文别名
CHPG(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
α-amino-2-chloro-5-hydroxybenzeneacetic acid
Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-
(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
CHPG价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-101364 | CHPG | 170846-74-9 | 1 mg | 1636元 |
| 2025/02/08 | HY-101364 | CHPG CHPG | 170846-74-9 | 5mg | 3600元 |
常见问题列表
生物活性
CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。靶点
|
mGlu 5
|
NF-κB
|
ERK
|
Akt
|
体外研究
CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
| Cell Line: | BV2 microglial cells |
| Concentration: | 10, 50, 100 and 500 µM |
| Incubation Time: | 24 hours |
| Result: | Increased the cell viability. |
Apoptosis Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
体内研究
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
| Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
| Dosage: | 250 nM |
| Administration: | Injection; for 7 days |
| Result: | Reduced significantly cerebral lesion volume. |