172377-52-5
中文名称
172377-52-5
英文名称
Motolimod
CAS
172377-52-5
分子式
C18H25NO4S
分子量
351.46
MOL 文件
172377-52-5.mol
更新日期
2023/03/20 15:41:25
172377-52-5 结构式
基本信息
中文别名
雌二醇 3-氨基磺酸 英文别名
E2MATEES-J 995
BLE 00084
Estradiol 3-sulfamate
Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate
172377-52-5价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 1mg | 2000元 |
| 2024/01/25 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 10mM * 1mLin DMSO | 3093元 |
| 2024/01/25 | HY-U00112 | 172377-52-5 Estradiol 3-sulfamate | 172377-52-5 | 5mg | 4000元 |
常见问题列表
生物活性
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) 是一种长效和有口服活性的类固醇硫酸酯酶 (steroid sulfatase) 抑制剂；抑制雌酮硫酸酯酶的 IC50 值为251 nM，Ki 值为133 nM。靶点
IC50: 251 nM (estrone sulfatase)
Ki: 133 nM (estrone sulfatase)
体外研究
Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity.
体内研究
Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors.