174689-39-5

中文名称 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

英文名称 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

CAS 174689-39-5

分子式 C21H27NO2.C2H2O4

分子量 415.48

MOL 文件 174689-39-5.mol

更新日期 2025/05/07 13:29:52

174689-39-5 结构式

基本信息物理化学性质安全数据图谱信息 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE价格(试剂级) 常见问题列表

基本信息

中文别名

化合物SR59230A
(S)-1-(2-乙基苯氧基)-3-(((S)-1,2,3,4-四氢萘-1-基)氨基)丙-2-醇草酸盐

英文别名

SR 59230A
SR59230AHCl
SR 59230A HYDROCHLORIDE
SR 59230A >=98% (HPLC), powder
3-(2-ETHYLPHENOXY)-1-((1S)-1,2,3,4-TETRA-HYDRONAPHTH-1-YLAMINO)-(2S)-2-PROPANOL OXALATE
(S)-1-(2-Ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol oxalate
3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
hyperthermia,adrenoceptor,Adrenergic Receptor,adrenergic,Beta Receptor,inhibit,hypothermia,receptor,Inhibitor,SR59230A,SR-59230A

物理化学性质

储存条件Store at RT

溶解度二甲基亚砜：>10mg/mL

形态粉末

颜色白色

安全数据

安全说明22-24/25

WGK Germany3

图谱信息

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE(174689-39-5)核磁图(¹HNMR)

常见问题列表

生物活性

SR59230A 是一种血脑屏障穿透性的、有效的 β3-adrenergic receptor 的选择性拮抗剂，对β3、β1和β2受体的IC50分别为40 nM、408 nM和648 nM。

靶点

Target	Value
β3-adrenergic receptor (Cell-free assay)	40 nM
β1-adrenergic receptor (Cell-free assay)	408 nM
β2-adrenergic receptor (Cell-free assay)	648 nM

体外研究

SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.

Cell Viability Assay

Cell Line:	Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C)
Concentration:	100 nM, 1 μM, 5 μM, 10 μM, and 50 μM
Incubation Time:	24 hours
Result:	Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1 µM for Neuro-2A cells and 5 µM for SK-N-BE(2) and BE(2)C).

体内研究

MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.

Animal Model:	Male C-57BL6J wild-type mice (22-35 g)
Dosage:	0.5 or 5 mg/kg
Administration:	Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).
Result:	Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.