178451-13-3
178451-13-3 结构式
基本信息
英文别名
Raloxifene Impurity 22Raloxifene 6-Methoxy Analog
Raloxifene 6-MonoMethyl Ether
Methanone, [2-(4-hydroxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
常见问题列表
生物活性
Raloxifene 6-Monomethyl Ether 是一种 Raloxifene 衍生物，其抑制雌激素受体 α (estrogen receptor α)。Raloxifene 4-Monomethyl Ether 抑制 MCF-7 细胞，IC50 为 250 nM，pIC50 为 6.6。体外研究
Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative with a methoxy group on C6. Raloxifene 6-Monomethyl Ether holds poor ICsub>50 value because of disruption to the hydrogen bond network and steric disfavor.