18296-44-1
中文名称
戊曲酯
英文名称
Valtrate
CAS
18296-44-1
分子式
C22H30O8
分子量
422.47
MOL 文件
18296-44-1.mol
更新日期
2024/04/22 10:47:44
18296-44-1 结构式
基本信息
中文别名
戊曲酯环氧戊喃
缬草三酯
戊曲酯标准品
戊曲酯对照品
戊曲酯/缬草素
缬草三酯(缬草素
戊曲酯,缬草三酯
缬草三酯(液体)
缬草素、环氧戊喃、戊曲酯
英文别名
ValtrateValtratuM
VALTRATE(P)
ValepotriatuM
HalazuchroMe B
Valtrate USP/EP/BP
VALTRATE(P)(PLEASE CALL)
(1S,7R)-4-Acetoxymethyl-6,7aα-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1α,6α-diol 1,6-bis(3-methylbutanoate)
[(1S,6S,7aS)-4-(Acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
Butanoic acid, 3-methyl-, 1,1'-[(1S,2'R,6S,7aS)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1H),2'-oxirane]-1,6-diyl] ester
所属类别
生物化工：中草药成分物理化学性质
外观性状黄色液体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于蛛蛛香，缬草。
沸点525.9±50.0 °C(Predicted)
密度1.22±0.1 g/cm3(Predicted)
储存条件Refrigerator
溶解度可溶于氯仿（轻微，超声处理），甲醇（轻微）
形态Oil
颜色浅棕色至深黄色
水溶解性微溶于水
常见问题列表
生物活性
Valepotriate, 从 Valeriana jatamansi 分离而来，具有抗癫痫和抗癌活性。体内研究
Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.