183204-74-2
中文名称
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
英文名称
5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
CAS
183204-74-2
分子式
C9H11ClN4O2
分子量
242.66
MOL 文件
183204-74-2.mol
更新日期
2024/06/17 17:25:36
183204-74-2 结构式
基本信息
中文别名
替吡嘧啶替比拉西
5-氯-6-[(2-亚氨基-1-吡咯烷基)甲基]-2,4(1H,3H)-嘧啶二酮
英文别名
MA 1 (pharmaceutical)TPI (thymidine phosphorylase inhibitor)
5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione
5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione,
2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-
所属类别
医药中间体：嘧啶类化合物物理化学性质
密度1.71±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度Water: 1 mg/mL (4.12 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
酸度系数(pKa)7.06±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
抑制剂
盐酸替吡嘧啶是一种有效的胸苷磷酸化酶抑制剂，当与三氟尿苷结合形成 TAS-102 时，可防止三氟尿苷快速降解，从而维持活性药物的足够血浆水平。生物活性
Tipiracil 是一种胸苷磷酸化酶 (TPase) 抑制剂。靶点
thymidine phosphorylase
体外研究
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer. Tipiracil prevents degradation of FTD through a first-pass effect as a thymidine phosphorylase inhibitor.