18455-98-6
18455-98-6 结构式
基本信息
中文别名
蜂斗菜内酯B蜂斗菜螺内酯
英文别名
FukinolideBakkenolide B
(-)-Bakkenolide B
(1'R,3R,7'aβ)-1'β-Acetoxy-3'aβ,4'β-dimethyl-4-methylene-7'α-[[(2Z)-2-methyl-2-butenoyl]oxy]spiro[oxolane-3,2'-hydrindane]-2-one
(Z)-2-Methyl-2-butenoic acid [(3R,3'aα)-3'α-acetoxy-4,5,1',3',3'a,4',5',6',7',7'a-decahydro-7'α,7'aα-dimethyl-4-methylene-2-oxospiro[furan-3(2H),2'-[2H]inden]-4'β-yl] ester
所属类别
天然产物：倍半萜蜂斗菜螺内酯价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2022/09/18 | HY-N7292 | 蜂斗菜螺内酯 Bakkenolide B | 18455-98-6 | 1mg | 4600元 |
| 2022/09/18 | HY-N7292 | 蜂斗菜螺内酯 Bakkenolide B | 18455-98-6 | 5mg | 13200元 |
常见问题列表
生物活性
Bakkenolide B 是从 petasites japonicas 叶片中分离出来的，具有抗过敏和抗炎作用。 Bakkenolide B 可用于研究哮喘。体外研究
Bakkenolide B (0-100 μg/ml; pretreatment 30 mins) inhibits antigen-induced β-hexosamidase release from RBL2H3 mast cells in a concentration-dependent manner.Bakkenolide B (0-10 μg/ml; 1 h later stimulated with LPS) strongly inhibits the gene inductions of inducible nitric oxide synthase and cyclooxygenase-2 in a concentration-dependent manner in mouse peritoneal macrophages.
Western Blot Analysis
| Cell Line: | Mouse peritoneal macrophages |
| Concentration: | 0 μg/ml; 1 μg/ml; 3 μg/ml; 5 μg/ml; 10 μg/ml |
| Incubation Time: | 1 h later stimulated with LPS |
| Result: | Decreased iNOS and cox-2 protein expression. |
体内研究
Bakkenolide B (intraperitoneal injection; 1 mg/ml; 1 h before ovalbumin nebulization on days 28, 29, and 30) strongly inhibits the accumulation of eosinophils, macrophages, and lymphocytes to bronchoalveolar lavage fluid (BALF) in ovalbumin-induced asthma mice.
| Animal Model: | Ovalbumin-induced asthma mice |
| Dosage: | 1 mg/ml |
| Administration: | Intraperitoneal injection; 1 h before ovalbumin nebulization on days 28, 29, and 30 |
| Result: | Exhibited anti-allergic effects in mice. |