187218-90-2

英文名称 SRA880

CAS 187218-90-2

分子式 C26H32N4O4

分子量 464.56

MOL 文件 187218-90-2.mol

187218-90-2 结构式

基本信息物理化学性质应用领域

基本信息

英文别名

SRA880 free base

物理化学性质

沸点684.2±55.0 °C(Predicted)

密度1.238±0.06 g/cm3(Predicted)

酸度系数(pKa)9.08±0.40(Predicted)

应用领域

用途一

SRA880 is a non-peptide somatostatin sst(1) receptor antagonist. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0) or a wide range of neurotransmitter receptors, except for the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.