187739-60-2
中文名称
CARBOXYAMIDOTRIAZOLE OROTATE
英文名称
CARBOXYAMIDOTRIAZOLE OROTATE
CAS
187739-60-2
分子式
C22H16Cl3N7O6
分子量
580.765
MOL 文件
187739-60-2.mol
更新日期
2023/03/20 15:41:25
187739-60-2 结构式
基本信息
中文别名
化合物CARBOXYAMIDOTRIAZOLE OROTATE 英文别名
CAI OrotateL-651582 Orotate
OCSMDRBVJRAMCI-UHFFFAOYSA-N
CARBOXYAMIDOTRIAZOLE OROTATE
CARBOXYAMIDOTRIAZOLE OROTATE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-16125 | CARBOXYAMIDOTRIAZOLE OROTATE Carboxyamidotriazole Orotate | 187739-60-2 | 5mg | 2000元 |
| 2024/04/30 | S2975 | CarboxyaMidotriazole orotate | 187739-60-2 | 5mg | 2211.3元 |
| 2024/04/30 | HY-16125 | CARBOXYAMIDOTRIAZOLE OROTATE Carboxyamidotriazole Orotate | 187739-60-2 | 10mg | 3000元 |
常见问题列表
生物活性
Carboxyamidotriazole Orotate (L-651582 Orotate)，是一种口服生物有效的信号转导抑制剂Carboxyamidotriazole (CAI) 的 orotate 盐形式。Carboxyamidotriazole Orotate 是一种非电压性钙通道 (nonvoltage-operated calcium channels) 和钙通道介导的信号通路 (calcium channel-mediated signaling pathways) 的细胞抑制剂，具有抗癌，抗炎活性和抗血管生成作用。体外研究
Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines.
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment.
Cell Viability Assay
| Cell Line: | LAMA84R and K562R cell lines |
| Concentration: | 0.1, 1, 5, 10 µM |
| Incubation Time: | 24, 48, 72, 96 hours |
| Result: | Showed a 50% growth reduction of the chronic myelogenous leukaemia (CML) lines with 5 µM CTO at 96 h time point. |
Western Blot Analysis
| Cell Line: | LAMA84R and K562R cell lines |
| Concentration: | 0.1, 1, 5 µM |
| Incubation Time: | 72 and 96 hours |
| Result: | A dose-dependent inhibition of both total and phosphorylated Bcr-Abl levels. |
体内研究
Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts.
| Animal Model: | Male NOD/SCID mice four-to-five week old |
| Dosage: | 342, 513 mg/kg |
| Administration: | i.p.; Q1D×5 for two rounds |
| Result: | Increase survival. |