187870-95-7

NHE1

Blocking NHE-1 activity has been shown to decrease intracellular Na ⁺ and Ca ²⁺ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.