1883650-96-1
中文名称
CPD1599
英文名称
CDDO-3-P-Im
CAS
1883650-96-1
分子式
C39H46N4O3
分子量
618.81
MOL 文件
1883650-96-1.mol
更新日期
2024/04/30 10:29:04
1883650-96-1 结构式
常见问题列表
生物活性
CDDO-2P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-2P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。体外研究
CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM.
CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 5.8 nM.
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 30 nM, 100 nM |
| Incubation Time: | 4 days |
| Result: | Induced differentiation of U937 cells at 100 nM. |
体内研究
CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
| Animal Model: | Seven week-old female A/J mice |
| Dosage: | 50 mg/kg, 200 mg/kg |
| Administration: | Diet; for 16 weeks |
| Result: | Decreased the number, the size and the severity of tumors. |