1917306-14-9

中文名称化合物 JNJ-61803534

英文名称 2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

CAS 1917306-14-9

分子式 C23H23Cl2F6N3O4S

分子量 622.41

MOL 文件 1917306-14-9.mol

1917306-14-9 结构式

基本信息物理化学性质应用领域常见问题列表

基本信息

中文别名

化合物 JNJ-61803534

英文别名

tert-butyl (3R
4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]-

物理化学性质

密度1.494±0.06 g/cm3(Predicted)

酸度系数(pKa)4.85±0.46(Predicted)

形态Solid

颜色White to off-white

应用领域

用途一

JNJ-61803534 is a novel potent RORγt inverse agonist, selectively inhibiting RORγt-driven transcription versus closely-related family members, RORα and RORβ, also inhibiting IL-17A production in human CD4+ T cells under Th17 differentiation conditions, but not inhibiting IFNγ production under Th1 differentiation conditions, and having neither impact on in vitro differentiation of regulatory T cells (Treg), nor on the suppressive activity of natural Tregs.

常见问题列表

概述

JNJ-61803534 是一种有效的、具有口服活性 RORγt 反向激动剂，IC50 为 9.6 nM。JNJ-61803534 具有抗炎活性。JNJ-61803534 在 Th17 分化条件下抑制人 CD4+ T 细胞产生 IL-17A。