1927857-55-3

中文名称化合物 PQR514

英文名称 2-Pyrimidinamine, 4-(difluoromethyl)-5-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-

CAS 1927857-55-3

分子式 C16H20F2N8O2

分子量 394.38

MOL 文件 1927857-55-3.mol

1927857-55-3 结构式

基本信息物理化学性质应用领域图谱信息

基本信息

中文别名

化合物 PQR514

英文别名

2-Pyrimidinamine, 4-(difluoromethyl)-5-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-

物理化学性质

沸点700.0±65.0 °C(Predicted)

密度1.420±0.06 g/cm3(Predicted)

酸度系数(pKa)4.80±0.10(Predicted)

应用领域

用途一

PQR514 is a potent pan-PI3K inhibitor (Ki 110alpha =2.2 nM). PQR514 is a follow-up compound for the phase-II clinical compound PQR309. PQR514 has an improved potency both in vitro and in cellular assays with respect to its predecessor compounds. It shows superiority in the suppression of cancer cell_x000D_ proliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309

图谱信息

化合物 PQR514(1927857-55-3)核磁图(¹HNMR)