1931109-55-5
英文名称
Tetradecanoic acid, 14-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-
CAS
1931109-55-5
分子式
C29H39NO4
分子量
465.62
MOL 文件
1931109-55-5.mol
1931109-55-5 结构式
基本信息
英文别名
14-(Fmoc-amino)-tetradecanoic acidTetradecanoic acid, 14-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-
应用领域
用途一
14-(Fmoc-amino)-tetradecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. 14-(Fmoc-amino)-tetradecanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.