19350-66-4
中文名称
2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER
英文名称
2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER
CAS
19350-66-4
分子式
C14H19NO6
分子量
297.3
MOL 文件
19350-66-4.mol
更新日期
2024/09/11 09:07:32
19350-66-4 结构式
基本信息
中文别名
3,5-二(乙氧羰基)-2,6-二甲基-1,4-二氢吡啶-4-羧酸 英文别名
AV-153 free base3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid
3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
物理化学性质
沸点450.5±45.0 °C(Predicted)
密度1.230±0.06 g/cm3(Predicted)
储存条件Inert atmosphere,Room Temperature
溶解度DMSO: 250 mg/mL (840.90 mM)
酸度系数(pKa)1.47±0.70(Predicted)
形态Solid
颜色White to light yellow
2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-135218A | 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER AV-153 free base | 19350-66-4 | 50mg | 210元 |
| 2025/02/08 | HY-135218A | 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER AV-153 free base | 19350-66-4 | 10mM * 1mLin DMSO | 231元 |
| 2025/02/08 | HY-135218A | 2,6-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3,4,5-TRICARBOXYLIC ACID 3,5-DIETHYL ESTER AV-153 free base | 19350-66-4 | 100 mg | 336元 |
常见问题列表
生物活性
AV-153 free base 是一种 1,4-dihydropyridine (1,4-DHP) 衍生物，具有抗突变作用。在体外人细胞内，AV-153 free base 可以插入到 DNA 的单链断裂处，减少 DNA 损伤并刺激 DNA 修复。AV-153 free base 可以与胸腺嘧啶和胞嘧啶相互作用，对聚 (ADP) 核糖基化有影响。AV-153 free base 具有抗癌活性。体外研究
AV-153 free base causes IC
50
s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively.
AV-153 free base (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67%.