1941174-13-5
中文名称
L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
英文名称
L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
CAS
1941174-13-5
分子式
C32H25N7O5
分子量
587.58
MOL 文件
1941174-13-5.mol
1941174-13-5 结构式
基本信息
中文别名
化合物 T32404 英文别名
KMH-233L-Phenylalanine, 3-[[[2,4-dicyano-3-[4-[2-(methylamino)-2-oxoethoxy]phenyl]pyrido[1,2-a]benzimidazol-1-yl]amino]carbonyl]-
物理化学性质
密度1.41±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : 100 mg/mL (170.19 mM)
酸度系数(pKa)2.16±0.10(Predicted)
形态Solid
颜色White to yellow
常见问题列表
生物活性
KMH-233 是一种有效，可逆的且选择性的 l 型氨基酸转运蛋白 1 (LAT1) 抑制剂，可抑制LAT1底物，l-leucin 的摄取 (IC50=18 μM) 以及细胞生长。即使在低浓度 (25 μM) 下，KMH-233 仍可显着增强 Bestatin 和顺铂的疗效。体外研究
KMH-233 is able to inhibit binding and transport of essential neutral amino acids and thus, inhibit the cell growth of cancer cells.
KMH-233 shows a significant reduction of cell growth with an IC
50
of 124 µM.
KMH-233 is effective and able to potentiate the anti-proliferative efficacy of Bestatin (100 µM) and Cisplatin (100 µM) at a lower concentration of 25 µM, inhibiting cell growth 53% and 50%, respectively.
Cell Proliferation Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 0.5-1000 μM |
| Incubation Time: | 72 hours |
| Result: | Showed a significant reduction of cell growth with an IC 50 of 124 µM. |