195822-23-2

中文名称 N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺

英文名称 LQZ-7I

CAS 195822-23-2

分子式 C20H14F2N4

分子量 348.35

MOL 文件 195822-23-2.mol

更新日期 2025/05/12 11:39:08

195822-23-2 结构式

基本信息物理化学性质安全数据 N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺价格(试剂级) 常见问题列表

基本信息

中文别名

化合物LQZ-7I
N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺

英文别名

LQZ-7I
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-

所属类别

医药中间体：喹啉类化合物

物理化学性质

熔点203 °C(Solv: ethanol (64-17-5))

沸点470.3±45.0 °C(Predicted)

密度1.390±0.06 g/cm3(Predicted)

储存条件Keep in dark place,Inert atmosphere,Room temperature

溶解度DMSO: 125 mg/mL (358.83 mM)

酸度系数(pKa)2.56±0.59(Predicted)

形态A solid

颜色Light yellow to green yellow

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS05,GHS07

警示词危险

危险性描述H302+H312+H332-H314

防范说明P501-P261-P270-P271-P264-P280-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405

N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-136538	N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺 LQZ-7I	195822-23-2	1 mg	380元
2025/02/08	HY-136538	N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺 LQZ-7I	195822-23-2	5mg	600元
2025/02/08	HY-136538	N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺 LQZ-7I	195822-23-2	10mM * 1mLin DMSO	660元

常见问题列表

生物活性

LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。

靶点

Survivin

体外研究

LQZ-7I has improved cytotoxicity with IC ₅₀ s of 3.1 µM against C4-2 cells and 4.8 µM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin.

Western Blot Analysis

Cell Line:	PC-3 or C4-2 cells
Concentration:	10 µM
Incubation Time:	0-6 hours
Result:	Reduced the expression of survivin.

体内研究

LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.

Animal Model:	6-week old male NSG mice
Dosage:	100 mg/kg; 200 µL vehicle (90% corn oil/10% DMSO)
Administration:	Oral gavage every other day for a total of ten treatments
Result:	Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.